Journal
PROGRESS IN LIPID RESEARCH
Volume 49, Issue 1, Pages 76-86Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2009.08.003
Keywords
Docosahexaenoic acid; Conjugated linoleic acids; Chemosensitization; Radiosensitization; PUFA; Breast cancer; Metastases; Adjuvant nutrition
Funding
- Institut National de la SantE et de la Recherche Medicale
- Ministries of Health and Research
- French National Cancer Institute
- Canceropole Grand-Ouest
- Center Region
- Ligue Nationale contre le Cancer
- University and Hospital of Tours
Ask authors/readers for more resources
Lifestyle and nutritional factors have been recognized to influence breast cancer survival, irrespective of genomic alterations that are the hallmarks of the disease. The biological and molecular mechanisms involved in the effects of dietary polyunsaturated fatty acids and breast cancer response to treatments in clinical and preclinical studies have been reviewed. Among nutrients, rumenic acid, a naturally occurring CLA isomer and n-3 docosahexaenoic acid (DHA) a highly unsaturated fatty acid, have emerged due to their potential to increase cancer treatment efficacy without additional side effects. In this review, we analyze the literature evidence that breast cancer treatment and outcome could be improved through an adjuvant dietary supplementation. Such an original approach would involve two successive phases of breast cancer treatment: an initial sensitization of residual tumor cells to chemotherapy and to radiation therapy with dietary DHA: then a prevention of metastatic re-growth with a prolonged rumenic acid supplementation. Safety is not anticipated to be a critical issue, although it has to be assessed in the long term. Dietary supplements, used in combination to anti-cancer agents, should be provided under medical prescription. Such an original use of fatty acids in breast cancer treatment could provide the lipid field with a new avenue to impact public health. (C) 2009 Elsevier Ltd. All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available