Journal
PROGRESS IN LIPID RESEARCH
Volume 47, Issue 1, Pages 50-61Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2007.10.002
Keywords
antifungal agents; malaria; marine fatty acids; methoxylated fatty acids; n-myristoyltransferase; plasmodium falciparum; sponges; topoisomerase I; tuberculosis
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008102] Funding Source: NIH RePORTER
- NIGMS NIH HHS [S06 GM008102-360070, S06GM08102, S06 GM008102] Funding Source: Medline
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This review deals with the most recent findings on the antimalarial, antimycobacterial, and antifungal properties of fatty acids, with particular emphasis on novel marine fatty acids. The first section deals with the most recent and some background literature on what has been the latest developments with respect to fatty acids as antimalarial agents and the importance of enzyme inhibition, in particular the inhibition of the enoyl-ACP reductase (FabI) of Plasmodium falciparum, the principal agent responsible for malaria. This section of the review also emphasizes the latest antimalarial research with the very long-chain Delta 5,9 fatty acids from sponges. The second section of the review deals with the recent literature on the antimycobacterial activity of fatty acids and the importance of enzyme inhibition, in particular the inhibition of the enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis for antimycobacterial activity. The inhibitory activities of the Delta 5,9 fatty acids against InhA as well as that of the alpha-methoxylated fatty acids are also discussed. The importance of Delta 5,9 fatty acids as topoisomerase I inhibitors and its connection to cancer is also reviewed. The last part of the review, the antifungal section, also emphasizes the most recent research with antifungal fatty acids and the importance of enzyme inhibition, in particular N-myristoyltransferase (NMT) inhibition, for antifungal activity. This last section of the review emphasizes the latest research with the alpha-methoxylated fatty acids but the importance of acetylenic fatty acids is also considered. (c) 2007 Elsevier Ltd. All rights reserved.
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