Journal
PROGRESS IN ELECTROMAGNETICS RESEARCH-PIER
Volume 147, Issue -, Pages 1-22Publisher
EMW PUBLISHING
DOI: 10.2528/PIER14032303
Keywords
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Funding
- National Institutes of Health (NIH) [DP1 EB016986, R01 CA186567, R01 EB016963, R01 CA157277, R01 CA159959]
- Microphotoacoustics, Inc.
- Endra, Inc.
- NATIONAL CANCER INSTITUTE [R01CA186567, R01CA157277, R01CA159959] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB016963, DP1EB016986] Funding Source: NIH RePORTER
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Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted along with the most recent imaging results.
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