Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 110, Issue 2-3, Pages 166-177Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2012.07.013
Keywords
Human induced pluripotent stem cell; Cardiac cell; Embryoid body; Electrophysiology; Contraction; Optical mapping
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Funding
- Maryland Stem Cell Research Fund [2008-MSCRFE-0084-00, 2011-MSCRFII-0008-00, 2008-MSCRFII-0379-00]
- NIH [S10 RR025544, R21 HL108210, U01HL099775, U01HL100397]
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Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease. (C) 2012 Elsevier Ltd. All rights reserved.
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