Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 104, Issue 1-3, Pages 2-21Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2010.03.002
Keywords
Cardiac; Cellular; Physiome; Electrophysiology; Mathematical modelling
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Funding
- Newton Institute Cambridge United Kingdom
- United Kingdom Engineering and Physical Sciences Research Council [FP/F059361/1]
- Biotechnology and Biological Sciences Research Council [BB/F01080X/1]
- European Commission [FP7-ICT-2007-224495]
- Nora Eccles Treadwell Foundation
- King Abdullah University of Science and Technology (KAUST) [KUK-C1-013-04]
- BBSRC [BB/F01080X/1] Funding Source: UKRI
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL072011] Funding Source: NIH RePORTER
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In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. (C) 2010 Elsevier Ltd. All rights reserved.
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