Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 103, Issue 1, Pages 142-147Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2010.01.001
Keywords
Pak1; S1P; Cardiac ischemia
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Funding
- Wellcome Trust
- British Heart Foundation
- National Institute of Health [RO1 HL 64035, PO1 HL 62426]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL062426, R01HL064035] Funding Source: NIH RePORTER
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Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (SIP) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase. (C) 2010 Published by Elsevier Ltd.
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