Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 102, Issue 2-3, Pages 136-155Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2010.05.006
Keywords
Cardiac electrophysiology; Bidomain; Computation
Categories
Funding
- EPSRC [EP/D048400/1]
- European Community [FP7/2007-2013, 223920]
- European Commission [224381, 224495]
- King Abdullah University of Science and Technology (KAUST) [KUK-C1-013-04]
- Engineering and Physical Sciences Research Council [EP/D048400/1] Funding Source: researchfish
- EPSRC [EP/D048400/1] Funding Source: UKRI
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Simulation of cardiac electrical activity using the bidomain equations can be a massively computationally demanding problem. This study provides a comprehensive guide to numerical bidomain modelling. Each component of bidomain simulations-discretisation, ODE-solution, linear system solution, and parallelisation-is discussed, and previously-used methods are reviewed, new methods are proposed, and issues which cause particular difficulty are highlighted. Particular attention is paid to the choice of stimulus currents, compatibility conditions for the equations, the solution of singular linear systems, and convergence of the numerical scheme. (C) 2010 Elsevier Ltd. All rights reserved.
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