Journal
NATURE COMMUNICATIONS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms7570
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Funding
- NIH [R01 EB017748, K08 CA163961, GM-94367]
- Damon Runyon Cancer Research Foundation [DRR-29-14]
- MSKCC Center
- MSKCC Technology Development Fund Grant
- Geoffrey Beene Cancer Research Center at MSKCC
- Shared Resources Award
- Dana Foundation Brain and Immuno-Imaging Grant
- Dana Neuroscience Scholar Award
- Bayer HealthCare Pharmaceuticals/RSNA Research Scholar Grant
- MSKCC Brain Tumor Center Grant
- Society of MSKCC Research Grant
- National Science Foundation [CHE-1151379]
- MSKCC Core Grant [P30 CA008748]
- National Science Foundation Integrative Graduate Education and Research Traineeship Grant (NSF) [IGERT 0965983]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1151379] Funding Source: National Science Foundation
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High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.
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