Journal
PROCESS BIOCHEMISTRY
Volume 47, Issue 5, Pages 887-891Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2012.02.005
Keywords
Aspergillus terreus; Fermentation; (+)-Terrein; Medium optimization
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Funding
- High-Tech Research and Development Program of China [2011AA09070203]
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Terrein has potential application in the fields of medicine, cosmetology and agriculture, however, the chemical synthesis of terrein with single configuration is a difficult task, and the biosynthesis of terrein always results in low production (ca. 0.33-400 mg/L). In this study, we reported an Aspergillus terreus strain PF26 which could produce (+)-terrein on a high level. After the selection of a suitable basic medium, the component concentrations were optimized using Plackett-Burman design and response surface methodology. Consequently, an optimal medium containing 28.41 g glucose, 23.18 g maltose, 20.00 g mannitol, 8.52 g malt extract, 10.00 g monosodium glutamate 10.00 g NH4Cl in 1 L ASW was obtained, and a high (+)-terrein production of 3.71 g/L fermentation broth was achieved, which represents the highest Fermentation production of (+)-terrein to date. The result highlighted the industry's potential of A. terreus strain PF26 in the production of bioactive (+)-terrein on a large-scale. (C) 2012 Elsevier Ltd. All rights reserved.
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