Journal
PROCESS BIOCHEMISTRY
Volume 45, Issue 1, Pages 25-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2009.07.020
Keywords
Phenyl ethanols; Phenyl ethanol derivatives; Transesterification reactions; Lipases; Ionic liquids
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The transesterification of 1-phenyl ethanol has been carried Out using lipases from Pseudomonas aeruginosa MTCC 5113, to obtain chirally pure aryl ethanols with good yield and excellent enantioselectivity. The lipase from A aeruginosa gave good conversion and moderate enantioselectivity (ee) in organic solvents, however, when the catalytic amount of ionic liquids were added in the reaction mixture, excellent enantioselectivity was obtained. Moreover, the change in enantiomer preference was seen in the presence of catalytic amount of ionic liquids. The findings revealed that hydrophobic ionic liquids (two-phase system) were the best solvents and 4-substituted aryl ethanols were the pre-eminent Substrates for such type of reactions. The preparative scale (5 g) transesterification of 1-phenylethanol using lipases from P. aeruginosa yielded S-(-)-1-phenyl ethanol with 39% yield and >99% ee in hexane and 46% yield and >99% ee in [BMIm][PF6]. (C) 2009 Elsevier Ltd. All rights reserved.
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