Journal
NATURE COMMUNICATIONS
Volume 6, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncomms10088
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Funding
- Fondation pour la Recherche Medicale (FRM)
- United Kingdom Medical Research Council (MRC) Grant [9536855]
- AXA research fund
- INSERM Avenir
- Agence Nationale de la Recherche (ANR) grant [ANR12 SAMA00201]
- MRC [G1000183, G1002231] Funding Source: UKRI
- Medical Research Council [G0001354, G1000183B, G1000183, G1002231, G0001354B] Funding Source: researchfish
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In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits.
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