Journal
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 276, Issue 1663, Pages 1823-1827Publisher
ROYAL SOC
DOI: 10.1098/rspb.2008.1846
Keywords
compensatory mutation; deleterious mutations; experimental evolution; epistasis; primary structure
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Funding
- Natural Sciences and Engineering Research Council of Canada postgraduate scholarship (NSERC PGS-B)
- University of British Columbia Paetzold Fellowship
- NSERC Discovery
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Compensatory mutations improve fitness in genotypes that contain deleterious mutations but have no beneficial effects otherwise. As such, compensatory mutations represent a very specific form of epistasis. We show that intragenic compensatory mutations occur non-randomly over gene sequence. Compensatory mutations are more likely to appear at some sites than others. Moreover, the sites of compensatory mutations are more likely than expected by chance to be near the site of the original deleterious mutation. Furthermore, compensatory mutations tend to occur more commonly in certain regions of the protein even when controlling for clustering around the site of the deleterious mutation. These results suggest that compensatory evolution at the protein level is partially predictable and may be convergent.
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