Journal
NATURE COMMUNICATIONS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms8030
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Funding
- NCCR 'RNA & Disease' - Swiss National Science Foundation
- Swiss National Science Foundation [31003 A_143388/1]
- Austrian Science Fund FWF [Y315, P23510]
- DOC-fFORTE fellowship of the Austrian Academy of Sciences OAW [23170, 23949]
- Austrian Science Fund (FWF) [Y 315] Funding Source: researchfish
- Austrian Science Fund (FWF) [P23510] Funding Source: Austrian Science Fund (FWF)
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Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA upregulation. Ectopic expression of vtRNA1-1, but not of the other vtRNA paralogues, results in an improved viral establishment and reduced apoptosis, a function located in the central domain of vtRNA1-1. Knockdown of the major vault protein has no effect on these phenotypes revealing that vtRNA1-1 and not the vault complex contributes to general cell death resistance. This study describes a NF-kappa B-mediated role of the non-coding vtRNA1-1 in inhibiting both the extrinsic and intrinsic apoptotic pathways.
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