Journal
ONCOLOGY LETTERS
Volume 10, Issue 2, Pages 595-599Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2015.3273
Keywords
cordycepin; cancer cells apoptosis; cell proliferation; caspase signal pathway
Categories
Funding
- Natural Scientific Foundation of Chinese Shandong Province [ZR2010CQ031, ZR2014CM046]
- Shanghai Key Lab of Human Performance, Shanghai University of Sport [11DZ2261100]
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Cordycepin, a 3-deoxyadenosine, is the predominant functional component of the fungus Cordyceps militaris, a traditional Chinese medicine. Previous studies investigating the inhibition of cancer cells by cordycepin identified that it not only promotes cell apoptosis, but also controls cell proliferation. Furthermore, studies have elucidated the molecular mechanisms of inhibiting cell proliferation by cordycepin binding the A3 adenosine receptor, activating G protein, inhibiting cAMP formation, decreasing glycogen synthase kinase-3 beta/beta-catenin activation and suppressing cyclin D1 and c-myc expression. The most significant signaling pathway in which cell apoptosis is induced by cordycepin is the caspase pathway. Cordycepin induces cell apoptosis via binding the DR3 receptor and consequently activating caspase-8/-3. Taken together, these studies demonstrate that cordycepin may be used as a natural medicine, as it can not only control tumor cell proliferation, but also induce cancer cell apoptosis.
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