Journal
PROCEEDINGS OF THE NUTRITION SOCIETY
Volume 71, Issue 1, Pages 166-174Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0029665111003272
Keywords
Glyceollins; Antioxidants; Anti-inflammatory activity; Anti-cancer activity; Soyabean
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Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [2010-0027204, 2011-0009782]
- National Research Foundation of Korea [2011-0009782] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Glyceollins, one family of phytoalexins, are de novo synthesised from daidzein in the soyabean upon exposure to some types of fungus. The efficiency of glyceollin production appears to be influenced by soyabean variety, fungal species, and the degree of physical damage to the soyabean. The compounds have been shown to have strong antioxidant and anti-inflammatory activities, and to inhibit the proliferation and migration of human aortic smooth muscle cells, suggesting their potential to prevent atherosclerosis. It has also been reported that glyceollins have inhibited the growth of prostate and breast cancer cells in xenograft animal models, which is probably due to their anti-oestrogenic activity. In essence, glyceollins deserve further animal and clinical studies to confirm their health benefits.
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