Related references
Note: Only part of the references are listed.LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner
Bisei Ohkawara et al.
HUMAN MOLECULAR GENETICS (2014)
Reversing LRP5-Dependent Osteoporosis and SOST Deficiency-Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
Ming-Kang Chang et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2014)
Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta
Christina M. Jacobsen et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2014)
Romosozumab in Postmenopausal Women with Low Bone Mineral Density
Michael R. McClung et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Severe Cenani-Lenz Syndrome Caused by Loss of LRP4 Function
Ariana Kariminejad et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2013)
Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation
Stevan R. Hubbard et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)
A common LRP4 haplotype is associated with bone mineral density and hip geometry in men Data from the Odense Androgen Study (OAS)
Eveline Boudin et al.
BONE (2013)
Systemic Administration of Sclerostin Antibody Enhances Bone Repair in a Critical-Sized Femoral Defect in a Rat Model
Mandeep S. Virk et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2013)
Sclerostin Antibody Improves Skeletal Parameters in a Brtl/+ Mouse Model of Osteogenesis Imperfecta
Benjamin P. Sinder et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
Standardized Nomenclature, Symbols, and Units for Bone Histomorphometry: A 2012 Update of the Report of the ASBMR Histomorphometry Nomenclature Committee
David W. Dempster et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron et al.
NATURE MEDICINE (2013)
Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome
Rajendra Kedlaya et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors
Gill Holdsworth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses
Norihiro Yumoto et al.
NATURE (2012)
WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
Hou-Feng Zheng et al.
PLOS GENETICS (2012)
Sclerostin: Therapeutic Horizons Based Upon Its Actions
Aline G. Costa et al.
CURRENT OSTEOPOROSIS REPORTS (2012)
Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
Su Jin Kim et al.
HUMAN GENETICS (2011)
Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function
Olivier Leupin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Inhibition of Sclerostin by Monoclonal Antibody Enhances Bone Healing and Improves Bone Density and Strength of Nonfractured Bones
Michael S. Ominsky et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
Eric Bourhis et al.
STRUCTURE (2011)
LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome
Yun Li et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Lrp4: A Novel Modulator of Extracellular Signaling in Craniofacial Organogenesis
Atsushi Ohazama et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2010)
Parathyroid Hormone (PTH)-Induced Bone Gain Is Blunted in SOST Overexpressing and Deficient Mice
Ina Kramer et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Wnt10b Deficiency Results in Age-Dependent Loss of Bone Mass and Progressive Reduction of Mesenchymal Progenitor Cells
Jennifer R. Stevens et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Two Doses of Sclerostin Antibody in Cynomolgus Monkeys Increases Bone Formation, Bone Mineral Density, and Bone Strength
Michael S. Ominsky et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Guidelines for Assessment of Bone Microstructure in Rodents Using Micro-Computed Tomography
Mary L. Bouxsein et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Osteoporosis: impact on health and economics
Nicholas Harvey et al.
NATURE REVIEWS RHEUMATOLOGY (2010)
Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation - A Mouse Model for Cenani-Lenz Syndrome
Courtney M. Karner et al.
PLOS ONE (2010)
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Seth A. Ettenberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
NMR structure of the Wnt modulator protein Sclerostin
Stella E. Weidauer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Fernando Rivadeneira et al.
NATURE GENETICS (2009)
The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
Wendy Balemans et al.
CALCIFIED TISSUE INTERNATIONAL (2008)
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
Xiaodong Li et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2008)
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo
Ming K. Chang et al.
JOURNAL OF IMMUNOLOGY (2008)
The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies
Christine Rothe et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Multiple genetic loci for bone mineral density and fractures
Unnur Styrkarsdottir et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development
Atsushi Ohazama et al.
PLOS ONE (2008)
DMP1-targeted Cre expression in odontoblasts and osteocytes
Y. Lu et al.
JOURNAL OF DENTAL RESEARCH (2007)
LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction
Scott D. Weatherbee et al.
DEVELOPMENT (2006)
Bone density ligand, sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
Debra L. Ellies et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2006)
Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice
EB Johnson et al.
HUMAN MOLECULAR GENETICS (2005)
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
KES Poole et al.
FASEB JOURNAL (2005)
SOST is a target gene for PTH in bone
H Keller et al.
BONE (2005)
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
M Semënov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
GG Loots et al.
GENOME RESEARCH (2005)
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
XF Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Regulation of osteoblastogenesis and bone mass by Wnt10b
CN Bennett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Nicotine decreases agrin signaling and acetylcholine receptor clustering in C2C12 myotube culture
AJ Ferayorni et al.
JOURNAL OF NEUROBIOLOGY (2004)
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
M Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population
K Staehling-Hampton et al.
AMERICAN JOURNAL OF MEDICAL GENETICS (2002)
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
ME Brunkow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Cenani-Lenz syndrome with renal hypoplasia is not linked to FORMIN or GREMLIN
C Bacchelli et al.
CLINICAL GENETICS (2001)
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
W Balemans et al.
HUMAN MOLECULAR GENETICS (2001)
Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34)
M Kneissel et al.
BONE (2001)