Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 51, Pages E5492-E5497Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1414499111
Keywords
gadolinium; imaging; in vivo PDT; survivin; tumor recognition
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Funding
- Hong Kong Research Grants Council [203112]
- HKBU [FRG 2/12-13/002]
- Hong Kong Polytechnic University [YL01, GUCO8]
- Partner State Key Laboratory of Environmental and Biological Analysis
- Strategic Development Fund of HKBU
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In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional-PDT and imaging-gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species-singlet oxygen-before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of precision medicine in line with stem cell and gene therapies as tools in cancer therapy.
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