Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 41, Pages 14657-14662Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1408453111
Keywords
stimulated Raman scattering; optical microcavity; mode splitting; optical sensor; label free
Categories
Funding
- 973 Program Grant [2013CB328704]
- National Science Foundation of China [11474011, 11222440, 11121091, 61435001]
- Beijing Natural Science Foundation Program Grant [4132058]
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Ultrasensitive nanoparticle detection holds great potential for early-stage diagnosis of human diseases and for environmental monitoring. In this work, we report for the first time, to our knowledge, single nanoparticle detection by monitoring the beat quency of split-mode Raman lasers in high-Q optical microcavities. We first demonstrate this method by controllably transferring single 50-nm-radius nanoparticles to and from the cavity surface using a fiber taper. We then realize real-time detection of single nanoparticles in an aqueous environment, with a record low detection limit of 20 nm in radius, without using additional for laser noise suppression. Because Raman scattering occurs in most materials under practically any pump wavelength, this Raman laser-based sensing method not only removes the need for doping the microcavity with a gain medium but also loosens the requirement of specific wavelength bands for the pump lasers, thus representing a significant step toward practical microlaser sensors.
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