Scalable production of mechanically tunable block polymers from sugar

Development of sustainable and biodegradable materials is essential for future growth of the chemical industry. For a renewable product to be commercially competitive, it must be economically viable on an industrial scale and possess properties akin or superior to existing petroleum-derived analogs. Few biobased polymers have met this formidable challenge. To address this challenge, we describe an efficient biobased route to the branched lactone, beta-methyl-delta-valerolactone (beta M delta VL), which can be transformed into a rubbery (i.e., low glass transition temperature) polymer. We further demonstrate that block copolymerization of beta M delta VL and lactide leads to a new class of high-performance polyesters with tunable mechanical properties. Key features of this work include the creation of a total biosynthetic route to produce beta M delta VL, an efficient semisynthetic approach that employs high-yielding chemical reactions to transform mevalonate to beta M delta VL, and the use of controlled polymerization techniques to produce well-defined PLA-P beta M delta VL-PLA triblock polymers, where PLA stands for poly (lactide). This comprehensive strategy offers an economically viable approach to sustainable plastics and elastomers for a broad range of applications.