Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 34, Pages 12283-12287Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1400472111
Keywords
killed vaccines; proteins; live vaccine; genetic engineering
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Vaccines have a history that started late in the 18th century. From the late 19th century, vaccines could be developed in the laboratory. However, in the 20th century, it became possible to develop vaccines based on immunologic markers. In the 21st century, molecular biology permits vaccine development that was not possible before.
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