Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 22, Pages 6863-6870Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1411264111
Keywords
circadian rhythms; chromatin; epigenetics; nuclear organization
Categories
Funding
- National Institutes of Health
- Merieux Research Grants
- King Abdullah University of Science and Technology
- INSERM
- European Molecular Biology Organization long-term fellowship
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Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in similar to 24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional-translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear hubs of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control.
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