Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 14, Pages 5083-5087Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1321054111
Keywords
Brownian motion; Saffman-Delbruck; internal membrane structure; drag force; micropipette aspiration
Categories
Funding
- Agence Nationale pour la Recherche
- Fondation Pierre-Gilles de Gennes
- France Parkinson
- Department of Energy [CM4]
- National Science Foundation-CAREER [DMS-0956210]
- Chinese Academy of Sciences [KJCX2.YW.W10]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0956210] Funding Source: National Science Foundation
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The lateral mobility of proteins within cell membranes is usually thought to be dependent on their size and modulated by local heterogeneities of the membrane. Experiments using single-particle tracking on reconstituted membranes demonstrate that protein diffusion is significantly influenced by the interplay of membrane curvature, membrane tension, and protein shape. We find that the curvature-coupled voltage-gated potassium channel (KvAP) undergoes a significant increase in protein mobility under tension, whereas the mobility of the curvature-neutral water channel aquaporin 0 (AQP0) is insensitive to it. Such observations are well explained in terms of an effective friction coefficient of the protein induced by the local membrane deformation.
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