Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 46, Pages 16262-16267Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1314814111
Keywords
false discovery rate; genome-wide association studies; metaanalysis; multiple comparisons; r value
Categories
Funding
- European Research Council (ERC) under the European Community [PSARPS-294519]
- Israel Science Foundation [2012896]
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We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e., needles in a haystack). Our proposal assigns an r value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available.
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