Related references
Note: Only part of the references are listed.Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features
Zhizhou Fang et al.
ACS CHEMICAL BIOLOGY (2013)
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
Jianchuan Wang et al.
BIOCHEMICAL JOURNAL (2013)
Selective 3-Phosphoinositide-Dependent Kinase 1 (PDK1) Inhibitors: Dissecting the Function and Pharmacology of PDK1
Jesus R. Medina
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors
Ayaz Najafov et al.
BIOCHEMICAL JOURNAL (2012)
Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
Katrien Busschots et al.
CHEMISTRY & BIOLOGY (2012)
2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept
Adriana Wilhehm et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
Ayaz Najafov et al.
BIOCHEMICAL JOURNAL (2011)
PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Katharine Ellwood-Yen et al.
CANCER RESEARCH (2011)
Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket
Laura A. Lopez-Garcia et al.
CHEMISTRY & BIOLOGY (2011)
Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors
Jesus R. Medina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
Natalia Jura et al.
MOLECULAR CELL (2011)
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Jack D. Sadowsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1
Linyi Wei et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
NATURE (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and 1H-15N TROSY Experiments
Brian J. Stockman et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Valerie Hindie et al.
NATURE CHEMICAL BIOLOGY (2009)
Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors
Kristin E. D. Coan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
Matthias Engel et al.
EMBO JOURNAL (2006)
Structure of the catalytic domain of human protein kinase C β II complexed with a bisindolylmaleimide inhibitor
Neil Grodsky et al.
BIOCHEMISTRY (2006)
Enzymes involved in the bioconversion of ester-based prodrugs
Bianca M. Liederer et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization
Z Nikolovska-Coleska et al.
ANALYTICAL BIOCHEMISTRY (2004)
Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: Challenges to the discovery scientist
K Beaumont et al.
CURRENT DRUG METABOLISM (2003)
A specific mechanism of nonspecific inhibition
SL McGovern et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
BJ Collins et al.
EMBO JOURNAL (2003)
Evaluation of fluorescent compound interference in 4 fluorescence polarization assays: 2 kinases, 1 protease, and 1 phosphatase
TC Turek-Etienne et al.
JOURNAL OF BIOMOLECULAR SCREENING (2003)
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang et al.
NATURE STRUCTURAL BIOLOGY (2002)
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
RM Biondi et al.
EMBO JOURNAL (2002)
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
RM Biondi et al.
EMBO JOURNAL (2001)
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
RM Biondi et al.
EMBO JOURNAL (2000)