Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 33, Pages 12217-12221Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1403643111
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Funding
- Deutsche Forschungsgemeinschaft [SA 1853/1-1]
- Alexander von Humboldt Fellowship
- National Medical Research Council [0041/2013]
- European Research Council
- Medical Research Council [1177572] Funding Source: researchfish
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Canonical models suggest that mechanisms of long-term memory consist of a synapse-specific, protein synthesis-independent induction phase (changes in synaptic weights/temporary tagging of such synapses) and, within adjacent dendritic compartments, a protein synthesis-dependent distribution phase that may accompany or immediately precede induction and whose protein products enable consolidation through synaptic capture. We now report that this distribution phase is competitive in a winner-take-all fashion when synapses potentiated at induction compete with each other for plasticity-related proteins. This finding highlights the importance of synaptic competition in creating stable long-lasting memory in neural networks without disruption.
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