Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 4, Pages 1167-1172Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1401965111
Keywords
transcriptome analysis; inflammation; sepsis; burn; trauma
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [25116526, 10301780, 80420397]
- Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [25242078, 26115529, 25116526, 25350989] Funding Source: KAKEN
Ask authors/readers for more resources
The use of mice as animal models has long been considered essential in modern biomedical research, but the role of mouse models in research was challenged by a recent report that genomic responses in mouse models poorly mimic human inflammatory diseases. Here we reevaluated the same gene expression datasets used in the previous study by focusing on genes whose expression levels were significantly changed in both humans and mice. Contrary to the previous findings, the gene expression levels in the mouse models showed extraordinarily significant correlations with those of the human conditions (Spearman's rank correlation coefficient: 0.43-0.68; genes changed in the same direction: 77-93%; P = 6.5 x 10(-11) to 1.2 x 10(-35)). Moreover, meta-analysis of those datasets revealed a number of pathways/biogroups commonly regulated by multiple conditions in humans and mice. These findings demonstrate that gene expression patterns in mouse models closely recapitulate those in human inflammatory conditions and strongly argue for the utility of mice as animal models of human disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available