Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 4, Pages 1310-1315Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1318602111
Keywords
nanoparticle characterization; NEMS; microfluidics; mechanical oscillators
Categories
Funding
- Institute for Collaborative Biotechnologies [W911NF-09-D-0001]
- US Army Research Office Center for Integration of Medicine and Innovative Technology [09-440]
- National Science Foundation [1129359]
- Koch Institute Support (core) [P30-CA14051]
- National Cancer Institute
- Directorate For Geosciences
- Division Of Ocean Sciences [1129359] Funding Source: National Science Foundation
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Physical characterization of nanoparticles is required for a wide range of applications. Nanomechanical resonators can quantify the mass of individual particles with detection limits down to a single atom in vacuum. However, applications are limited because performance is severely degraded in solution. Suspended micro- and nanochannel resonators have opened up the possibility of achieving vacuum-level precision for samples in the aqueous environment and a noise equivalent mass resolution of 27 attograms in 1-kHz bandwidth was previously achieved by Lee et al. [(2010) Nano Lett 10(7): 2537-2542]. Here, we report on a series of advancements that have improved the resolution by more than 30-fold, to 0.85 attograms in the same bandwidth, approaching the thermomechanical noise limit and enabling precise quantification of particles down to 10 nm with a throughput of more than 18,000 particles per hour. We demonstrate the potential of this capability by comparing the mass distributions of exosomes produced by different cell types and by characterizing the yield of self-assembled DNA nanoparticle structures.
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