Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 31, Pages 11539-11544Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1412050111
Keywords
light signaling; ordinary differential equation
Categories
Funding
- National Natural Science Foundation [31330048]
- National Basic Research Program of China [2012CB910900]
- Natural Science Foundation [MCB-0929100]
- National Institutes of Health [GM47850]
- China Postdoctoral Science Foundation [2012M510266, 2013T60032, 2013M530009]
- State Key Laboratory of Protein and Plant Gene Research at Peking University
- Peking-Tsinghua Center for Life Sciences
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0929100] Funding Source: National Science Foundation
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Long-wavelength and low-fluence UV-B light is an informational signal known to induce photomorphogenic development in plants. Using the model plant Arabidopsis thaliana, a variety of factors involved in UV-B-specific signaling have been experimentally characterized over the past decade, including the UV-B light receptor UV resistance locus 8; the positive regulators constitutive photomorphogenesis 1 and elongated hypocotyl 5; and the negative regulators cullin4, repressor of UV-B photomorphogenesis 1 (RUP1), and RUP2. Individual genetic and molecular studies have revealed that these proteins function in either positive or negative regulatory capacities for the sufficient and balanced transduction of photomorphogenic UV-B signal. Less is known, however, regarding how these signaling events are systematically linked. In our study, we use a systems biology approach to investigate the dynamic behaviors and correlations of multiple signaling components involved in Arabidopsis UV-B-induced photomorphogenesis. We define a mathematical representation of photomorphogenic UV-B signaling at a temporal scale. Supplemented with experimental validation, our computational modeling demonstrates the functional interaction that occurs among different protein complexes in early and prolonged response to photomorphogenic UV-B.
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