Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 9, Pages 3229-3236Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1218525110
Keywords
bacterial roles animal origins; reciprocal effects animal-bacterial genomics; bacteria-driven development; microbiome and host physiology; nested ecosystems
Categories
Funding
- National Science Foundation [EF-0905606]
- John Simon Guggenheim Foundation
- Gordon and Betty Moore Foundation Visiting Scholar Program at the California Institute of Technology
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [841507, 1265171] Funding Source: National Science Foundation
Ask authors/readers for more resources
In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other's genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal-bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available