Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 7, Pages 2557-2562Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1222796110
Keywords
genetics; translation; tRNA synthetase; demethylase
Categories
Funding
- UK Medical Research Council (MRC) [G9824984]
- European Union [FP7-HEALTH-2009-241592 EurOCHIP]
- Wellcome Trust [093136]
- MRC Centre for Obesity and Related Metabolic Disorders
- [FP7-FOOD-266408 Full4Health]
- Medical Research Council [MC_UU_12012/5, G0900554, G0600717, MC_U142661184, G0600717B, G9824984] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10380] Funding Source: researchfish
- MRC [G0900554, G0600717, G9824984, MC_UU_12012/5, MC_U142661184] Funding Source: UKRI
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SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.
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