Related references
Note: Only part of the references are listed.Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition
Ketan S. Gajiwala et al.
STRUCTURE (2013)
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
Yibing Shan et al.
CELL (2012)
The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation
Silvia Lovera et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
Shunzhou Wan et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Biomolecular dynamics: order-disorder transitions and energy landscapes
Paul C. Whitford et al.
REPORTS ON PROGRESS IN PHYSICS (2012)
Comparison of Three Perturbation Molecular Dynamics Methods for Modeling Conformational Transitions
He Huang et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2009)
A conserved protonation-dependent switch controls drug binding in the Abl kinase
Yibing Shan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories
Sichun Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ligand-induced global transitions in the catalytic domain of protein kinase A
Changbong Hyeon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
Ashley C. W. Pike et al.
EMBO JOURNAL (2008)
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Xuewu Zhang et al.
NATURE (2007)
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
Huaibin Chen et al.
MOLECULAR CELL (2007)
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70
Sebastian Deindl et al.
CELL (2007)
Conformational transitions of adenylate kinase: Switching by cracking
Paul C. Whitford et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Comparison of multiple amber force fields and development of improved protein backbone parameters
Viktor Hornak et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Xuewu Zhang et al.
CELL (2006)
Computational sampling of a cryptic drug binding site in a protein receptor: Explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase
Tamara Frembgen-Kesner et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Src kinase activation: A switched electrostatic network
E Ozkirimli et al.
PROTEIN SCIENCE (2006)
A Src-like inactive conformation in the Abl tyrosine kinase domain
Nicholas M. Levinson et al.
PLOS BIOLOGY (2006)
Release of ADP from the catalytic subunit of protein kinase A: A molecular dynamics simulation study
BZ Lu et al.
PROTEIN SCIENCE (2005)
Gaussian split Ewald: A fast Ewald mesh method for molecular simulation
YB Shan et al.
JOURNAL OF CHEMICAL PHYSICS (2005)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
ER Wood et al.
CANCER RESEARCH (2004)
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
M Wolf-Watz et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
O Miyashita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Structural basis for the autoinhibition of c-Abl tyrosine kinase
B Nagar et al.
CELL (2003)
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
J Stamos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The conformational plasticity of protein kinases
M Huse et al.
CELL (2002)
Kinetic and catalytic mechanisms of protein kinases
JA Adams
CHEMICAL REVIEWS (2001)
Dynamic coupling between the SH2 and SH3 domains of c-Src and hck underlies their inactivation by C-terminal tyrosine phosphorylation
MA Young et al.
CELL (2001)
Untangling the ErbB signalling network
Y Yarden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Modification of the generalized Born model suitable for macromolecules
A Onufriev et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2000)