Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 3, Pages 1156-1161Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1321399111
Keywords
magnetic resonance imaging; voxel-based morphometry; unipolar depression; hippocampus
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Funding
- Swiss National Science Foundation (National Center for Competence in Research Synapsy) [320030_135679]
- Sonderprogramm Universitaetsmedizin [33CM30_140332/1]
- Foundation Parkinson Switzerland
- Foundation Synapsis
- Novartis Foundation
- Deutsche Forschungsgemeinschaft [Kfo 247]
- Swiss National Science Foundation (SNF) [320030_135679] Funding Source: Swiss National Science Foundation (SNF)
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There remains much scientific, clinical, and ethical controversy concerning the use of electroconvulsive therapy (ECT) for psychiatric disorders stemming from a lack of information and knowledge about how such treatment might work, given its nonspecific and spatially unfocused nature. The mode of action of ECT has even been ascribed to a barbaric form of placebo effect. Here we show differential, highly specific, spatially distributed effects of ECT on regional brain structure in two populations: patients with unipolar or bipolar disorder. Unipolar and bipolar disorders respond differentially to ECT and the associated local brain-volume changes, which occur in areas previously associated with these diseases, correlate with symptom severity and the therapeutic effect. Our unique evidence shows that electrophysical therapeutic effects, although applied generally, take on regional significance through interactions with brain pathophysiology.
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