Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 51, Pages 20575-20580Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1320454110
Keywords
insulin; cyclic AMP; nitric oxide; Cushing disease
Categories
Funding
- US Public Health Service [MH18501]
- National Research Foundation of Korea [2011-0030711, 2011-0015665]
- Korean government, Ministry of Science, ICT and Future Planning (MSIP)
- National Research Foundation of Korea [2011-0015665, 2011-0030711] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and diet-induced weight gain are diminished in the mutant mice.
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