Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 22, Pages 9106-9111Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1306912110
Keywords
adult neurogenesis; interneuron
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Funding
- Human Frontier Science Program
- James S. McDonnell Foundation
- Mather's Foundation
- National Institute of Mental Health [R01MH063912, R37 NS037075]
- Ellison Foundation
- JPB Foundation
- Sandia National Laboratories
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New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.
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