4.8 Article

Graphene quantum point contact transistor for DNA sensing

Publisher

NATL ACAD SCIENCES
DOI: 10.1073/pnas.1308885110

Keywords

solid-state membrane; transport; bio-molecule; simulation

Funding

  1. Oxford Nanopore Technology
  2. National Institutes of Health (NIH) [9P41GM104601]
  3. NIH [5 R01 GMO98243-02]

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By using the nonequilibrium Green's function technique, we show that the shape of the edge, the carrier concentration, and the position and size of a nanopore in graphene nanoribbons can strongly affect its electronic conductance as well as its sensitivity to external charges. This technique, combined with a self-consistent Poisson-Boltzmann formalism to account for ion charge screening in solution, is able to detect the rotational and positional conformation of a DNA strand inside the nanopore. In particular, we show that a graphene membrane with quantum point contact geometry exhibits greater electrical sensitivity than a uniform armchair geometry provided that the carrier concentration is tuned to enhance charge detection. We propose a membrane design that contains an electrical gate in a configuration similar to a field-effect transistor for a graphene-based DNA sensing device.

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