Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 17, Pages 7056-7061Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1219385110
Keywords
cortical development; microRNAs
Categories
Funding
- Wellcome Trust [83213]
- Medical Research Council, UK
- Medical Research Council [G0800429, MR/J003662/1, MR/J013137/1] Funding Source: researchfish
- MRC [MR/J013137/1, G0800429, MR/J003662/1] Funding Source: UKRI
Ask authors/readers for more resources
Cerebral cortical neurons arise from radial glia (direct neurogenesis) or from intermediate progenitors (indirect neurogenesis); intriguingly, the sizes of intermediate progenitor populations and the cortices they generate correlate across species. The generation of intermediate progenitors is regulated by the transcription factor Tbr2, whose expression marks these cells. We investigated how this mechanism might be controlled. We found that acute blockade of mature microRNA biosynthesis in murine cortical progenitors caused a rapid cell autonomous increase in numbers of Tbr2-expressing cells. Acute microRNA-92b (miR-92b) gain of function caused rapid reductions in numbers of Tbr2-expressing cells and proliferating intermediate progenitors. Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available