Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 5, Pages 1821-1826Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1221306110
Keywords
immune response; lymphocyte traffic; pulmonary lymphocyte
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Funding
- Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases
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The proportion of CD4 T cells with phenotypic and functional properties of naive cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of similar to 14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naive CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7(-/-) cells, lung naive CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-independent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naive CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-lung-to-lymph node route.
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