Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 6, Pages 2223-2227Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1221359110
Keywords
ancient DNA; human evolution; nuclear capture strategy; paleogenetics
Categories
Funding
- The Max Planck Society
- The Max Planck Society, Presidential Innovation Fund
- Chinese Academy of Sciences Strategic Priority Research Program [XDA05130202]
- Basic Research Data Projects [2007FY110200]
- Ministry of Science and Technology of China
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Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (similar to 30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
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