Journal
CURRENT ONCOLOGY REPORTS
Volume 17, Issue 12, Pages -Publisher
SPRINGER
DOI: 10.1007/s11912-015-0481-x
Keywords
Constipation; Probiotics; Prokinetics; Lubiprostone; Linaclotide; Transporter; Mu receptor; Antagonist
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Constipation is common in the general population and for those on opioids and/or who are suffering from advanced cancer. Self-management consists of dietary changes, exercise, and laxatives. However, responses to selfmanagement efforts are often inadequate to relieve the subjective and objective experience of constipation. Multiple new anti-constipating medications have recently been tested in randomized trials and the following are available commercially: probiotics, prucalopride, lubiprostone, linaclotide, elobixibat, antidepressants, methylnaltrexone, alvimopan, and naloxegol. This review will discuss the evidence-based benefits of these medications and outline an approach to managing constipation.
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