Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 12, Pages 4732-4737Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1300869110
Keywords
amnesia; navigation
Categories
Funding
- Medical Research Service of the Department of Veterans Affairs
- National Science Foundation [1120395]
- National Institute of Mental Health [24600]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1120395] Funding Source: National Science Foundation
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The hippocampus and other medial temporal lobe structures have been linked to both memory and spatial cognition, but it has been unclear how these ideas are connected. We carried out parallel studies of path integration in patients with medial temporal lobe lesions and rats with hippocampal lesions. Subjects entered a circular arena without vision, searched for a target, and then attempted to return to the start location. Patients performed accurately, and as well as controls, so long as the outward path was relatively direct and the target was found within 20 s. In sharp contrast, rats with hippocampal lesions were impaired, even when the outward path was shorter than 1 m, involved no turns, and the target was found within 3 s. We suggest that patients succeeded because performance could be supported by working memory and that patients and rats differ after hippocampal lesions in their ability to construct a coherent working memory of spatial environments.
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