4.8 Article

Rat brains also have a default mode network

Publisher

NATL ACAD SCIENCES
DOI: 10.1073/pnas.1200506109

Keywords

functional MRI; resting state; intrinsic activity; connectivity; spontaneous fluctuation

Funding

  1. National Institute on Drug Abuse, National Institutes of Health
  2. National Institute of Neurological Disorders and Stroke [NS06833]
  3. China's National Strategic Basic Research Program (973) [2012CB720700]

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The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function (s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.

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