Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 28, Pages E1972-E1979Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1208003109
Keywords
innate immunity; type three effectors; next-generation sequencing
Categories
Funding
- National Science Foundation/BREAD (Basic Research to Enable Agricultural Development) grant [0965418]
- NIFA (National Institute of Food and Agriculture) [2011-67012-30662]
- Direct For Biological Sciences [0965418] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems [0965418] Funding Source: National Science Foundation
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Cassava bacterial blight (CBB), incited by Xanthomonas axonopodis pv. manihotis (Xam), is the most important bacterial disease of cassava, a staple food source for millions of people in developing countries. Here we present a widely applicable strategy for elucidating the virulence components of a pathogen population. We report Illumina-based draft genomes for 65 Xam strains and deduce the phylogenetic relatedness of Xam across the areas where cassava is grown. Using an extensive database of effector proteins from animal and plant pathogens, we identify the effector repertoire for each sequenced strain and use a comparative sequence analysis to deduce the least polymorphic of the conserved effectors. These highly conserved effectors have been maintained over 11 countries, three continents, and 70 y of evolution and as such represent ideal targets for developing resistance strategies.
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