Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 7, Pages 2485-2490Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1115369109
Keywords
lung memory B cells; viral immunity
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology in Japan
- Japan Science and Technology Agency, Core Research for Evolutional Science and Technology
- Emerging and Re-Emerging Infectious Diseases and Regulatory Science of Pharmaceuticals and Medical Devices of the Ministry of Health, Labour and Welfare in Japan
- Grants-in-Aid for Scientific Research [23380073, 21229007, 23790553] Funding Source: KAKEN
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After pulmonary virus infection, virus-binding B cells ectopically accumulate in the lung. However, their contribution to protective immunity against reinfecting viruses remains unknown. Here, we show the phenotypes and protective functions of virus-binding memory B cells that persist in the lung following pulmonary infection with influenza virus. A fraction of virus-binding B-cell population in the lung expressed surface markers for splenic mature memory B cells (CD73, CD80, and CD273) along with CD69 and CXCR3 that are up-regulated on lung effector/memory T cells. The lung B-cell population with memory phenotype persisted for more than 5 mo after infection, and on reinfection promptly differentiated into plasma cells that produced virus-neutralizing antibodies locally. This production of local IgG and IgA neutralizing antibody was correlated with reduced virus spread in adapted hosts. Our data demonstrates that infected lungs harbor a memory B-cell subset with distinctive phenotype and ability to provide protection against pulmonary virus reinfection.
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