Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 33, Pages 13386-13391Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1203668109
Keywords
Archaea; hyperthermophile; virion structure
Categories
Funding
- Programme Blanc of the Agence Nationale de la Recherche, France [ANR 09-BLN-0288.01]
- Bourse du Gouvernement Francais [Dossier 2008661]
- Allocations Pasteur-Weizmann
- European Molecular Biology Organization [ALTF 347-2010]
- Grants-in-Aid for Scientific Research [20248023] Funding Source: KAKEN
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Known viruses build their particles using a restricted number of redundant structural solutions. Here, we describe the Aeropyrum coil-shaped virus (ACV), of the hyperthermophilic archaeon Aeropyrum pernix, with a virion architecture not previously observed in the viral world. The nonenveloped, hollow, cylindrical virion is formed from a coiling fiber, which consists of two intertwining halves of a single circular nucleoprotein. The virus ACV is also exceptional for its genomic properties. It is the only virus with a single-stranded (ss) DNA genome among the known hyperthermophilic archaeal viruses. Moreover, the size of its circular genome, 24,893 nt, is double that of the largest known ssDNA genome, suggesting an efficient solution for keeping ssDNA intact at 90-95 degrees C, the optimal temperature range of A. pernix growth. The genome content of ACV is in line with its unique morphology and confirms that ACV is not closely related to any known virus.
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