Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 48, Pages 19739-19744Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1208927109
Keywords
Cellular Potts Model; intravital imaging; HSV-1
Categories
Funding
- Netherlands Organization for Scientific Research [912.10.066]
- Veni Grant [916.86.080]
- European Research Council Grant Life-his-T
- [917.10.330]
- [175.010.2007.00]
- BBSRC [BBS/E/J/000C0645] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0645] Funding Source: researchfish
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Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they encounter newly infected target cells. Here we demonstrate that antigen-specific CD8(+) T cells that remain in skin following herpes simplex virus infection show a steady-state crawling behavior in between keratinocytes. Spatially explicit simulations of the migration of these tissue-resident memory T cells indicate that the migratory dendritic behavior of these cells allows the detection of antigen-expressing target cells in physiologically relevant time frames of minutes to hours. Furthermore, we provide direct evidence for the identification of rare antigen-expressing epithelial cells by skin-patrolling memory T cells in vivo. These data demonstrate the existence of skin patrol by memory T cells and reveal the value of this patrol in the rapid detection of renewed infections at a previously infected site.
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