Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 47, Pages 19196-19201Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1206376109
Keywords
drug discovery; antibiotic; secondary metabolite; genome mining
Categories
Funding
- NSERC [RGPIN 371576-2009, RGPIN 238748-2011]
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Nonribosomal peptides are highly sought after for their therapeutic applications. As with other natural products, dereplication of known compounds and focused discovery of new agents within this class are central concerns of modern natural product-based drug discovery. Development of a chemoinformatic library-based and informatic search strategy for natural products (iSNAP) has been constructed and applied to nonribosomal peptides and proved useful for true nontargeted dereplication across a spectrum of nonribosomal peptides and within natural product extracts.
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