Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 37, Pages 14746-14753Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1207726109
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- National Institutes of Health [R01GM068042]
- Centre National de la Recherche Scientifique
- University Paris VII
- Institut Universitaire de France, La Ligue National Contre le Cancer (Comite de Paris)
- Groupement d'entreprises francaises dans la lutte contre le cancer (GEFLUC)
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We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the interactome, and signaling pathways. The implications of gene balance are discussed.
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