Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 15, Pages 5856-5861Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1111133109
Keywords
complexity; integration
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Funding
- Belgian Fonds National de la Recherche Scientifique
- Fondation Medicale Reine Elisabeth
- University of Liege
- Fonds National de la Recherche Scientifique
- European Sleep Research Society
- Erwin Schrodinger fellowship of the Austrian Science Fund [J2470-B02]
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Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis that impaired consciousness during NREM sleep is associated with an increased modularity of brain activity. Cerebral connectivity was quantified in resting-state functional magnetic resonance imaging times series acquired in 13 healthy volunteers during wakefulness and NREM sleep. The analysis revealed a modification of the hierarchical organization of large-scale networks into smaller independent modules during NREM sleep, independently from EEG markers of the slow oscillation. Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep.
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