Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 14, Pages 5190-5195Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1117293109
Keywords
bone mineral; cell membranes
Categories
Funding
- National Science Foundation (NSF) [DMR-0653377]
- Yale Institute for Nanoscience and Quantum Engineering
- Yale Medical School's Magnetic Resonance Research Center
- Yale Core Center for Quantitative Neuroscience with Magnetic Resonance [1P30NS052519-01A1]
- National Institute for Neurological Disorders and Stroke
- micro-CT Core of the Yale Core Center for Musculoskeletal Disorders [AR46032]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Heart, Lung, and Blood Institute [R01 HL51018]
- NSF [DGE-0644492]
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Magnetic resonance imaging (MRI) of solids is rarely attempted. One of the main reasons is that the broader MR linewidths, compared to the narrow resonance of the hydrogen (H-1) in free water, limit both the attainable spatial resolution and the signal-to-noise ratio. Basic physics research, stimulated by the quest to build a quantum computer, gave rise to a unique MR pulse sequence that offers a solution to this long-standing problem. The quadratic echo significantly narrows the broad MR spectrum of solids. Applying field gradients in sync with this line-narrowing sequence offers a fresh approach to carry out MRI of hard and soft solids with high spatial resolution and with a wide range of potential uses. Here we demonstrate that this method can be used to carry out three-dimensional MRI of the phosphorus (P-31) in ex vivo bone and soft tissue samples.
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