Journal
EPIGENOMICS
Volume 7, Issue 8, Pages 1365-1378Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.82
Keywords
alternative lengthening of telomeres; ATRX; cancer; chromatin; DAXX; DNA replication; G quadruplexes; histone H3.3; p53; telomeres
Categories
Funding
- Cancer Research Society (CRS)
- Department of Oncology Catalyst Grant fund
- NSERC fellowship
Ask authors/readers for more resources
ATRX was identified over 20 years ago as the gene responsible for a rare developmental disorder characterized by alpha-thalassemia and intellectual disability. Similarities to the sucrose nonfermentable SNF2 type chromatin remodelers initially suggested a role in transcriptional regulation. However, over the last years, our knowledge of the epigenetic activities of ATRX has expanded steadily. Recent exciting discoveries have propelled ATRX into the limelight of chromatin and telomere biology, development and cancer research. This review summarizes recent breakthroughs in understanding ATRX function in heterochromatin structure, genome stability and its frequent dysregulation in a variety of cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available